I use a CO2 checker and keep it in the green, so approximately 25 - 35 ppm CO2. I haven't actually used a 5lb CO2 tank, so I was approximating based on the chart. I know a single charge on my 600g generator lasts 2-3 months. It is pretty well dialed in now. A lot can depend on how heavily stocked your tank is as well, since the animals will contribute to the CO2, probably only 2-5 ppm. Also, how dense your plantings are since more plants equals more CO2 uptake during the day.
Another contributing factor is surface exchange and the amount of CO2 in the air in your fish room. I'd strongly encourage folks to get a CO2 monitor, and not just for the fish room. Especially if you have a relatively modern, energy-efficient home.
I posted this somewhere, but I'll repeat the short version here. I was having issues keeping my
pH up in my saltwater aquarium, so I was considering buying a CO2 scrubber. Before purchasing one (I did BTW), I bought a CO2 monitor and put it in my reef room. Much to my surprise, the CO2 ppm averaged 1000-1200 and was as high as 1900+. As a reference, the outside CO2 is about 425 PPM where I live.
Anything over 1000 ppm is considered unhealthy. Since it isn't feasible to keep my windows open all the time, I installed a whole-home ERV (Energy Recovery Ventilator) to constantly bring in fresh air. This lowered my CO2 ppm in-home to around 600-800, with some occasional spikes to around 1000 ppm.
The downside, if you want to call it that, is I'm now using more CO2 on my freshwater tanks. The upside is we feel better, and I'm not having issues keeping the pH up in my Reef Tank
I don't have enough data yet to know how much more CO2 I'll be using, but regardless, I think it was worth reducing the in-home CO2