Part of the routine when you are treating ich is to vacuum the substrate with every water change and addition of more medication ( malachite green- formaldehyde) . This constant vacuuming of the substrate is more likely to disturb the bacteria numbers than using the above medication at the recommended dose IMO. Possibility every 3 days, for at least a fortnight after the last spots are seen , if that is what your brand recommends?
I have never had an issue but that does not mean one can relax when putting poison in the water.
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