**CindiL**

- #1

I keep reading here advice to not use Prime within 24 hours of using Tetra Safe Start. This didn't make sense to me because Prime binds ammonia and nitrites into non-toxic forms but it is still available for the bio-filter. Not using Prime allows ammonia or nitrites to harm your fish in that 24 hours you are not using it.

Anyways, I emailed Seachem to ask them and this is what they said:

If anyone thinks this is not correct, maybe email Tetra and we'll see what they say also to see if it coincides with Seachem's response.

Anyways, I emailed Seachem to ask them and this is what they said:

*Hello Cindi,*

Thank you for your email. Prime should not interfere with bacteria-start products, and in fact we highly recommend it as a part of any aquarium startup. I think that the confusion comes from the fact that Prime will bind ammonia and nitrite in a nontoxic form, but it will not actually remove them from the tank. They will, for instance, still be readable with test kits. While bound in the nontoxic form, the ammonia and nitrite is still available to the bacteria for utilization and removal, so using Prime can help to cycle the tank without harming the fish.

I hope this helps,

Seachem Support 10256

Thank you for your email. Prime should not interfere with bacteria-start products, and in fact we highly recommend it as a part of any aquarium startup. I think that the confusion comes from the fact that Prime will bind ammonia and nitrite in a nontoxic form, but it will not actually remove them from the tank. They will, for instance, still be readable with test kits. While bound in the nontoxic form, the ammonia and nitrite is still available to the bacteria for utilization and removal, so using Prime can help to cycle the tank without harming the fish.

I hope this helps,

Seachem Support 10256

If anyone thinks this is not correct, maybe email Tetra and we'll see what they say also to see if it coincides with Seachem's response.