I've been thinking about it, and I was wondering if you could do a fish-in cycle and just use Prime dechlorinator to keep your fish safe, thereby skipping water changes? I'd assume it's more efficient this way as there's more ammonia in the tank for the colonies to use. The only counter to this idea that I could see is that nitrifiers can't use ammonia that binds with prime. Any thoughts and reasons this wouldn't work? There has to be something wrong with this in my eyes.