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I have a 29 gallon tank that was treated with Bio Spira about a week ago, but...long story short, some stuff-non toxic, but messy got into my tank & I had to do a couple 30 % water changes to get it cleaned up. There are two convicts in there & they have recently hatched out a bunch of babies. Everything was low all week long. Amonia is low...almost no-presnet, but in just two days, the nitrites & nitrates have come up real high. I can't see the expense of ordering Bio Spira again. I could use Amquel+ to tie up the toxins. I could also use cycle in conjunction with that & water changes. Can you use both products at the same time & might there be any reaction with the BIo Spira?, but I can't imagine much is left in there. Your help is greatly appreciated! I put way more faith in you guys...even over the Petco people. You guys no your stuff.