Camallanus And Levamisole

vandzung2510

Hello everyone. I have some questions to ask about Camallanus and how to cure it with Levamisole.
Right now, I have 8 guppies, 1 swordtail and 2 goldfishes in my 66 litre tank. One of the guppy have the red thingy (which is camallanus) coming out of her anus, so i've dosed API General Cure into the tank a week ago. It temporary cure/kill/paralize the camallanus, because I haven't seen the parasite coming out of her again. That said, I will use levamisole to kill ALL of it, because I know metrodinazol won't work on them.
But today, I notice that the swordtail have a very long white/goo-y poop coming out of him. Is this the early sign of camallanus inside of him ? Sometimes, other guppies have that white poop too.
As some of you may have known, Levamisole HCl and Levamisole is very different. Levamisole HCl can dissolve in water, and therefore can pour into the tank to cure the camallanus. Levamisole HCl is light sensitive too, so it lost its power in extreme light. Levamisole on the other hand, don't dissolve very good in water; it lost its power in water with pH greater than 7.
So my next question is: Even though Levamisole lost its power in water with pH greater than 7, can I just leave the fish hungry for a day, and then pour the Levamisole powder straight into the tank so the fish can eat it ?

P/s: All of my guppies only swim near the surface. Some of them sometimes goes around the tank when the light turn off, but it when back to near the surface when the light turn on. Is this symptom also cause by the Camallanus ?
Thank you.
 

Inactive User

Levamisole HCl and Levamisole is very different. Levamisole HCl can dissolve in water, and therefore can pour into the tank to cure the camallanus. Levamisole HCl is light sensitive too, so it lost its power in extreme light. Levamisole on the other hand, don't dissolve very good in water; it lost its power in water with greater than 7.
So my next question is: Even though Levamisole lost its power in water with pH greater than 7, can I just leave the fish hungry for a day, and then pour the Levamisole powder straight into the tank so the fish can eat it ?

From what I understand, both the free base and chlorhydrate salt of levamisole decompose under increasing alkalinity; it's not a property exclusive to levamisole HCl.

Dry dosing the free base as oral administration is, I think, fraught with issues: will the fish eat or reject the powder, can the insoluble free base be sufficiently absorbed by the gastrointestinal tract, will the fish eat a therapeutic, non-therapeutic or a toxic dose, etc.

My line of thinking is that it's better to source the chlorhydrate salt. In particular, my fish disease diagnosis and treatment manual cites only levamisole chlorhydrate (rather than levamisole phosphate or free base levamisole) as an anthelmintic.

It might also be worth confirming whether the product you have is in fact the free base or the chlorhydrate salt: I can't speak for other countries, but in Australia at least, levamisole is nearly always sold as a chlorhydrate salt but is sometimes just labelled as "levamisole".
 

angelcraze

I've never used Levamisole in food because I get HCI, but I have added Fenbenzadole to food to treat callamanus worms. I would guess that Levamisole would be better accepted mixed into food though (if it's even effective, I'm not sure) because I highly doubt the fish would eat straight Levamisole.

I use Repashy gel food 'grub pie' formula to add meds too. My fish loved the Fenben food!

Hopefully someone knows about using Levamisole in food. You are correct that you need HCI to dissolve in the water.

In case you haven't seen it, here's a great link for Levamisole HCI use
 

vandzung2510

Thank you for your advice
 

LeviS

Hey, did you treat your fish? I treated mine today and just wondered what happened? If you treated them or still researching?
 

vandzung2510

Hey, did you treat your fish? I treated mine today and just wondered what happened? If you treated them or still researching?
Sorry for late respond. I haven't treat them yet, because since the day I use API GC, I haven't seen any of it, or any kind of white poop coming out of them. They are very "active/energetic/dynamic" (sorry I don't know what word to use). That said, i've just bought some Levamisole HCl today (the closet pet medicine store that have Levamisole HCl is 10+ kilometers away from my home, so I have a hard time buying it). In the next hour (when I turn of my tank's light system), I will use it in my tank. So let's hope for the best
 

angelcraze

It's interesting to hear you saw an improvement using GC. Metro and PrazI were said to not be effective against callamanus. So it's been about 2 weeks since you've treated with GC?
 

vandzung2510

It's interesting to hear you saw an improvement using GC. Metro and PrazI were said to not be effective against callamanus. So it's been about 2 weeks since you've treated with GC?
Yes. I'm quite suprise about it too, as I do know the fact that Metro and PrazI don't usually work on camallanus. Until yesterday, I haven't seen any camallanus coming out of any fish. But I do see some white/clear poop coming out from some of the fish. So I still dose some LevaHCl into the tank.
 

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