In my experience the hardest part is getting Neons that do not have the Neon Tetra Disease (NTD). As mentioned, stock is not great. If they make it and get used to the tank, they are easy. I lost two schools of Neons before, only 2 of the second school survived. I got 10 more and they were healthy so they are doing great. They even survived a recent rescape I did in which I tore my aquarium down and had to put all my fish in a temporary 20 gal. They are back in the 46g and doing good.