I apologize in advance for all the questions, but for anyone to help you figure out what's happening, we need information.
Have you tested your water for
ammonia/nitrites/nitrates? If so, how did you test and what were the readings? If not, getting a good liquid
test kit and doing so would be a reasonable first step.
When the 11 neons died, did they exhibit the same symptoms as the pleco, or something else? Have there been any symptoms besides lethargy and bloating? Do any of the other fish in the tank show any signs of illness?
You said you treated the water... what did you treat for, and what did you use to treat?
When was the last time you added a new fish or plant to the tank?