You can vacuum out the gravel - I think the damage from rotting food would be worse than the damage of cleaning it out. Perhaps you could clean the uneaten food out with the water change?
If the fish won't eat the medicated food, you might try soaking it in garlic juice before feeding it to them. If they won't eat that, then you might need to get the Parasite Clear or Clout.
Daphnia is a light, floating food that you can often feed to fish that won't eat other food. It also can work in a manner similiar to peas in clearing constipation.
Quote:
Originally Posted by Faye Rod
While I was away over the weekend the Anti Parasite medicated fish food by Jungle arrived and my husband went ahead and started the 3 day a week dosage....which we will repeat as directed for four weeks.
Question: I need to do my 25% water change. My husband said the fish really didn't want to eat the stuff when he put it in.....can I vacuum the gravel?
Also: CoBetta Dave recommended Daphia to someone and I ordered it....but I can't remember why it was recommended! What is a good schedule for feeding the variety of community fish I have? I have been doing fish flakes twice a day for three days...then dry blood worms or frozen brine shrimp...then back to flakes. I'll go ahead and check for past posts about this. I'm sure it's already been covered somewhere 
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