Our CAE's (around 1.5 years old) have never picked on any fish smaller than themselves. The one harassed our parrot cichlids during the short time they were housed together, presumably because he felt threatened by them. Other than that one instance they have never shown any aggressive behavior nor have they caused any fish any harm. They do an excellent job of keeping the tank clean (aside from the plastic plants.)
If the CAE hasn't bothered the Oto by now there's little chance that it's going to, although it COULD possibly run into the little guy while tearing around the tank as CAE's are known to do.
There's also the fact that the Oto will be able to hide in places where the CAE could never go.
I don't mean to start an argument, but I've always been bothered by the bad rap that CAE's have, which is 97% contradictory to my experience with them. I've found Pleco's to be much more trouble. I tend to give advice based on my experience, and I've found our CAE's to be hardy, helpful, and generally peaceful fish.
On a side note it sounds like your tank is pretty heavily stocked, and a CAE is best kept in a 55 gallon or larger tank. You will have to be very diligent at keeping your nitrates low, I've read that Otos are particularly sensitive to
nitrate toxicity.