How long have you had your tank and have you done the Nitrogen Cycle on the tank?*
http://www.fishlore.com/NitrogenCycle.htm
Do you have the testing equipment to do tests for ammonia, nitrites, and nitrates?*
If so can you give us the results of the tests?
How often do you do water changes and how much - 30% 40% 50%?*
What size is the tank?*
How many fish do you have in there and what kind?*
Are you running an airstone in the tank?*
What temperature do you keep the tank at?
What kind of filter do you have in the tank?
I know this is a lot to ask but we really do need the information to give you an intelligent answer.* In the meantime, I would do a large (75% water change) and start an airstone and airpump.* This will at least take care of the two main possible problems for a day.* (ammonia poisoning in an uncycled tank and oxygen starvation).* Also the temperature of the tank should be about 80 degrees for the health of the fish.
Rose