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i would absolutely use both filters. there's no such thing as too much filtration.
i would put the intake tube for the canister in the back right corner of the tank. with the outlet bar from the middle of the tank horizontally to the right. i would position the HOB filter on the far left side of the tank. putting the intakes close to the gravel is good, imo too. the reason i would set up like this is because if you think about the current of the water, the output bars/section are all on the left, and will create a sort of horizontal 'cyclone' shaped current pushing debris and water to the right.
i've not looked at the magnum 330, but i would be very surprised if it didn't have shut off valves on both tubes. they may be on the canister itself?
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