Once your tank is cycled there should not be toxic levels of ammonia or
nitrite that you would NEED prime. But prime does more than just make ammonia and nitrite non toxic. It conditions the water against
chlorine,
chloramine, heavy metals, AND stimulates the slime coat. So it is good to use as directed, but I would wait until after your cycle is complete, and all the different bacteria have a good chance to establish strong populations in your tank.
Once again the link I gave you will explain more about it.
